Potassium Carbonate → HCID 90290199, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	Trimethylboroxine	HCID 574072	—
Reactant	HCID 90290198	HCID 90290198	—
Catalyst	Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)	HCID 178418228	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	HCID 90290199	HCID 90290199	—

Reaction Conditions

Temperature	100 °C

Reaction Steps

To a flask of 47A (255 mg, 0.37 mmol) in dioxane, K2CO3 (179 mg, 1.30 mmol), PdCl2(dppf) (27 mg, 0.037 mmol) and trimethyl boroxine (0.052 mL, 0.37 mmol) was added to the mixture. The reaction mixture was heated at 100° C. for 3 h. The reaction was cooled down and the solution partitioned between water and EtOAc. The aqueous phase was extracted with EtOAc and the combined extracts dried, filtered and concentrated in vacuo. The crude product was purified by flash chromatography to provide the title compound. MS (m/z) 621 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09050344B2
Source dataset	uspto-grants-2015_06
ORD ID	ord-12cf5e2e30d046d2afd9a9a0b7c2c45f
Source note	uspto-grants-2015_06