Ammonium Hydroxide → HCID 90290175, compound

Participants

Reaction Conditions

Reaction Steps

In a high pressure reaction vessel, a suspension of 59B (300 mg, 0.742 mmol) in dioxane (2 mL) was treated with ammonium hydroxide (28%) (3 mL) and heated at 90° C. overnight. Solvents were removed and the crude was purified by flash chromatography to provide the title compound: 1H NMR (400 MHz, methanol-d4) δ 8.17 (d, 1H), 7.33-6.97 (m, 2H), 6.84-6.31 (m, 4H), 5.25 (m, 1H), 4.65 (s, 1H), 3.42 (d, 2H), 3.27-2.96 (m, 6H), 2.47 (m, 2H), 1.38 (m, 1H), 1.05 (m, 1H). MS (m/z) 385 [M+H]+.

Provenance & Evidence