Nitrogen → HCID 58261495, compound

Participants

Reaction Steps

51 g (298 mmol) of 1-naphthylboronic acid, 100 g (298 mmol) of diethyl chlorobromoterephthalate and 144 g (626 mmol) of potassium phosphate monohydrate are initially introduced in a mixture of 600 ml of dist. water, 400 ml of toluene and 200 ml of dioxane and saturated with N2 for 30 min. 5.4 g (18 mmol) of tri(o-tolyl)phosphine and 669 mg (3 mmol) of palladium(II) acetate are subsequently added, and the mixture is heated at the boil for 3 h. After dilution with toluene, the organic phase is separated off, washed twice with water, dried over Na2SO4 and evaporated in vacuo. The oil which remains is distilled in a thin-film evaporator (p=5×10−3 mbar, T=130° C.) and isolated in the form of a yellow oil (74 g, 65%), which, according to 1H-NMR, has a purity of >95%.

Provenance & Evidence