Sodium Bicarbonate → HCID 68452705, compound

Participants

Reaction Conditions

Reaction Steps

400 mL of an aqueous solution containing 9.8 g of Lipase PS Amano SD was added to a solution of 98.4 g (387 mmol) of the acetylated form (Compound 5) dissolved in 300 mL of acetonitrile, and agitated at 40° C. overnight. At the end of the reaction, a saturated aqueous sodium hydrogen carbonate solution was added, followed by extraction with ethyl acetate. The organic layer was washed with saturated saline, dried with anhydrous sodium sulfate, filtrated, and subjected to vacuum concentration to obtain 84.2 g of a crude product (crude yield: 75.8%). The obtained crude product was subjected to column purification (n-Hex:AcOEt=3:1) to obtain 62.3 g of a mixture of Compounds 9 and 10 as a yellow oily product.

Provenance & Evidence