Acetonitrile → HCID 68452705, compound

Participants

Reaction Conditions

Reaction Steps

570 mL of an acetonitrile solution containing 190 g of Compound 5 was heated to 40° C., to which 760 mL of an aqueous solution containing 19 g Lipase PS Amano SD was added and the resultant was agitated for 15 hours while maintaining the temperature at 40° C. After confirming the end of the reaction by thin-layer chromatography, the resultant was left to cool at room temperature, added with water and subjected to extraction with ethyl acetate. The organic layer was concentrated to obtain 148 g of a mixture of Compounds 9 and 10 as a clear brown oily product (crude yield: 93.8%).

Provenance & Evidence