Sodium Hydroxide → HCID 59583418, compound

Participants

Reaction Steps

To a solution of methyl 1-(2-biphenylylmethyl)-5-methyl-1H-1,2,3-triazole-4-carboxylate (Intermediate 6) (1.1 g, 3.58 mmol) in methanol was added an aqueous solution of sodium hydroxide (7.2 mL, 6 mmol). The solution was heated at reflux for 3 hours. After concentration under reduced pressure, a 1N HCl solution (8 mL) was added. The resulting solid material was filtered, washed with water and dried to give the title compound as a cream solid (810 mg, 77%). LC/MS: m/z 294 (M+H)+, Rt: 2.23 min.

Provenance & Evidence