Sodium Hydroxide → HCID 42603325, compound

HRID 2170541Notes

Reaction equation

HRID 2170541 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][N:10]2[C:14]([CH3:15])=[C:13]([C:16]([NH:18][C:19]3[CH:20]=[C:21]([CH:27]=[CH:28][CH:29]=3)[C:22]([O:24]CC)=[O:23])=[O:17])[N:12]=[N:11]2)[CH:5]=[CH:6][C:7]=1[Cl:8].[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][N:10]2[C:14]([CH3:15])=[C:13]([C:16]([NH:18][C:19]3[CH:20]=[C:21]([CH:27]=[CH:28][CH:29]=3)[C:22]([OH:24])=[O:23])=[O:17])[N:12]=[N:11]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 42603009HCID 42603009, compound

Product 1

HCID 42603325HCID 42603325, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of ethyl 3-[({1-[(3,4-dichlorophenyl)methyl]-5-methyl-1H-1,2,3-triazol-4-yl}carbonyl)amino]benzoate (Example 20) (0.06 g, 0.138 mmol) and a 1N NaOH solution (2 mL, 2 mmol) in ethanol (5 mL) was stirred at 40° C. for 4 hours. The solvent was evaporated and the residue was acidified with a 1N HCl solution. The precipitate formed was filtered and dried. The title compound was obtained as a white solid (53 mg, 96%). HRMS calculated for C18H14Cl2N4O5 (M+H)+: 405.0521. found: 405.0520, Rt: 2.23 min. MP: 267.6° C.

Workup

  1. customThe solvent was evaporated
  2. customThe precipitate formed
  3. filtrationwas filtered
  4. customdried

Sources & evidence

ORD record
ord-235ed1b81a6d4e95a4a68fe2bba0cd73
Source dataset
uspto-grants-2015_06
Patent number
US09051281B2

Reaction notes

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