N-(3,5-Bis(hydroxymethyl)phenyl)-1-((3,4-dichlorophenyl)methyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide → {5-[({1-[(3,4-Dichlorophenyl)methyl]-5-methyl-1H-1,2,3-triazol-4-yl}methyl)amino]benzene-1,3-diyl}dimethanol

Participants

Reaction Steps

This compound was obtained as a by product of the reduction of dimethyl 5-[({1-[(3,4-dichlorophenyl)methyl]-5-methyl-1H-1,2,3-triazol-4-yl}carbonyl)amino]-1,3-benzenedicarboxylate (Intermediate 14) in the preparation of N-[3,5-bis(hydroxymethyl)phenyl]-1-[(3,4-dichlorophenyl)methyl]-5-methyl-1H-1,2,3-triazole-4-carboxamide (Example 52). It was obtained as a white solid (5%) via recrystallisation from acetonitrile. HRMS calculated for C19H20Cl2N4O2 (M+H)+407.1042. found: 407.1022, Rt: 2.40 min. MP: 120° C.

Provenance & Evidence