참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Anisole | HCID 7519 | — |
| 반응물 | 1h-Pyrazole-3-carboxamide,4-[3-(hydroxymethyl)phenyl]-1-[(4-methoxyphenyl)methyl]-n-phenyl- | HCID 66855422 | — |
| 용매 | Trifluoroacetic acid | HCID 6422 | — |
| 생성물 | HCID 178521930 | HCID 178521930 | 35.2% |
반응 단계
A mixture of 4-(3-hydroxymethyl-phenyl)-1-(4-methoxy-benzyl)-1H-pyrazole-3-carboxylic acid phenylamide (20 mg) and anisole (20 μl) in trifluoroacetic acid (1 ml) was heated at 120° C. (50 W) for 15 minutes in a CEM Discover microwave synthesiser. The reaction was evaporated then purified by flash column chromatography eluting with 2:1 ethyl acetate/hexane. Product containing fractions were combined and evaporated to give 5 mg of product. (LC/MS: Rt 2.55 [M+H]+ 294).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09051278B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_06 |
|---|
| ORD ID | ord-69419559b26b47888d902a61cb4915f7 |
|---|
| 출처 메모 | uspto-grants-2015_06 |
|---|
