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HRID21706

反应详情

EQUATION

反应方程式

HRID 21706 的结构方程式

REACTANTS

反应物

1
结构：C[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]1C(=O)N(CC(=O)OC(C)(C)C)[C@@H]1[C@@H](C)C(=O)OCc1ccccc1
HCID10255617

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]1C(=O)N(CC(=O)OC(C)(C)C)[C@@H]1[C@@H](C)C(=O)O
HCID10476973

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[C].[Pd]
催化剂HCID178418390

未命名化合物

结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A solution of (3S,4S)-3-[(1R)-1-t-butyldimethylsilyloxyethyl]-4-[(1R)-1-benzyloxycarbonylethyl]-1-(t-butyloxycarbonylmethyl)azetidin-2-one (0.45 g) in 99.5% ethanol (6 ml) was subjected to hydrogenation at room temperature in the presence of 10% palladium-carbon (90 mg) under atmospheric pressure, followed by filtration to remove the catalyst. The filtrate was evaporated to give (3S,4S)-3-[(1R)-1-t-butyldimethylsilyloxyethyl]-4-[(1R)-1-carboxyethyl]-1-(t-butyloxycarbonylmethyl)azetidin-2-one.

WORKUP

后处理

  1. filtrationfollowed by filtration
  2. customto remove the catalyst
  3. customThe filtrate was evaporated