HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 71074983, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-(Bromomethyl)-2,4-difluorobenzene | HCID 90297 | — |
| Reactant | Ethyl 2,3-dimethyl-1H-indole-5-carboxylate | HCID 612460 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 71074983 | HCID 71074983 | — |
Reaction Steps
NaH (1.1 equiv) was added to a solution of ethyl 2,3-dimethyl-1H-indole-5-carboxylate in DMF at room temperature. After 30 min, 2,4-difluorobenzyl bromide (1.1 equiv) was added to the reaction mixture and stirred for 1 h. After the reaction was completed, the solvent was removed in vacuo to obtain the crude which was purified by flash chromatography to obtain the compound. LC-MS 344 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09051265B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-5afd9f184b2a4c8fb490c5d649ddc3ea |
| Source note | uspto-grants-2015_06 |