反应详情

温度

50 °C

To a solution of ethyl 2,3-dimethyl-1H-indole-5-carboxylate (500 mg, 2.3 mmol) in ethanol (10 mL) was added a 5N NaOH solution (9.2 mL). The resulting solution was heated at 50° C. for 4 h, and then quenched carefully by addition of a 6N HCl solution (10 mL). The mixture was diluted with ethyl acetate, washed with a 0.5 N HCl solution and brine, dried on MgSO4, and concentrated to afford a yellow powder (500 mg, 100%). ESI-MS (m/z): 190 [MH]+

1. customquenched carefully by addition of a 6N HCl solution (10 mL)
2. additionThe mixture was diluted with ethyl acetate
3. washwashed with a 0.5 N HCl solution and brine
4. customdried on MgSO4
5. concentrationconcentrated