HCID 86674580, compound → HCID 71109545, compound

HRID 2170623Notes

Reaction equation

HRID 2170623 reaction equation
[CH3:1][C:2]1[N:3]([CH2:26][C:27]2[CH:32]=[CH:31][C:30]([C:33]3([C:36]([O:38][CH3:39])=[O:37])[CH2:35][CH2:34]3)=[CH:29][CH:28]=2)[C:4]2[C:9]([C:10]=1[CH3:11])=[CH:8][C:7]([C:12](=[O:25])[NH:13][C@H:14]([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([CH3:24])=[CH2:23])[CH:17]=1)[CH3:15])=[CH:6][CH:5]=2>CCO.[Pd]>[CH:22]([C:18]1[CH:17]=[C:16]([C@@H:14]([NH:13][C:12]([C:7]2[CH:8]=[C:9]3[C:4](=[CH:5][CH:6]=2)[N:3]([CH2:26][C:27]2[CH:28]=[CH:29][C:30]([C:33]4([C:36]([O:38][CH3:39])=[O:37])[CH2:35][CH2:34]4)=[CH:31][CH:32]=2)[C:2]([CH3:1])=[C:10]3[CH3:11])=[O:25])[CH3:15])[CH:21]=[CH:20][CH:19]=1)([CH3:24])[CH3:23]

Participants

4

Reactant 1

HCID 86674580HCID 86674580, compound

Product 1

HCID 71109545HCID 71109545, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of (S)-methyl 1-(4-((2,3-dimethyl-5-((1-(3-(prop-1-en-2-yl)phenyl)ethyl)carbamoyl)-1H-indol-1-yl)methyl)phenyl)cyclopropanecarboxylate in EtOH (5 mL) was added Pd/C 10%. The resulting mixture was stirred for 5 h under hydrogen atmosphere. The solution was then filtered and concentrated to afford a yellow oil which was directly used without further purification. ESI-MS (m/z): 523 [MH]+

Workup

  1. filtrationThe solution was then filtered
  2. concentrationconcentrated
  3. customto afford a yellow oil which
  4. customwas directly used without further purification

Sources & evidence

ORD record
ord-7697af02c1f74e6c8d97fe6e8d2b7c3f
Source dataset
uspto-grants-2015_06
Patent number
US09051265B2

Reaction notes

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