HCID 71075704, compound → HCID 71075785, compound

HRID 2170630Notes

Reaction equation

Cl.[CH:2]([C:5]1[CH:6]=[C:7]([C@@H:11]([NH2:13])[CH3:12])[CH:8]=[CH:9][CH:10]=1)([CH3:4])[CH3:3].[CH3:14][O:15][C:16](=[O:40])[CH2:17][O:18][C:19]1[CH:20]=[C:21]([CH:37]=[CH:38][CH:39]=1)[CH2:22][N:23]1[C:31]2[C:26](=[CH:27][C:28]([C:32](O)=[O:33])=[CH:29][CH:30]=2)[C:25]([CH3:35])=[C:24]1[CH3:36]>>[CH:2]([C:5]1[CH:6]=[C:7]([C@@H:11]([NH:13][C:32]([C:28]2[CH:27]=[C:26]3[C:31](=[CH:30][CH:29]=2)[N:23]([CH2:22][C:21]2[CH:20]=[C:19]([CH:39]=[CH:38][CH:37]=2)[O:18][CH2:17][C:16]([O:15][CH3:14])=[O:40])[C:24]([CH3:36])=[C:25]3[CH3:35])=[O:33])[CH3:12])[CH:8]=[CH:9][CH:10]=1)([CH3:4])[CH3:3]

Participants

Reactant 2

HCID 71075704HCID 71075704, compound

HCID 86674569HCID 86674569, compound

Product 1

HCID 71075785HCID 71075785, compound

Procedure

The title compound was prepared following the same protocol as described in Step 5, Example 36, using the (S)-1-(3-isopropylphenyl)ethanamine hydrochloride instead of the (S)-1-(3-cyclopropylphenyl)ethanamine hydrochloride and the 1-(3-(2-methoxy-2-oxoethoxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid instead of the 1-(4-(2-methoxy-2-oxoethoxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid.

Sources & evidence

ORD record: ord-68b989116d7244bd95490f7918944cab
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09051265B2

Reaction notes

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