HCID 71075704, compound → HCID 71075180, compound

HRID 2170631Notes

Reaction equation

HRID 2170631 reaction equation
Cl.[C:2]([C:6]1[CH:11]=[CH:10][C:9]([C@@H:12]([NH2:14])[CH3:13])=[CH:8][CH:7]=1)([CH3:5])([CH3:4])[CH3:3].[CH3:15][O:16][C:17](=[O:41])[CH2:18][O:19][C:20]1[CH:21]=[C:22]([CH:38]=[CH:39][CH:40]=1)[CH2:23][N:24]1[C:32]2[C:27](=[CH:28][C:29]([C:33](O)=[O:34])=[CH:30][CH:31]=2)[C:26]([CH3:36])=[C:25]1[CH3:37]>>[C:2]([C:6]1[CH:7]=[CH:8][C:9]([C@@H:12]([NH:14][C:33]([C:29]2[CH:28]=[C:27]3[C:32](=[CH:31][CH:30]=2)[N:24]([CH2:23][C:22]2[CH:21]=[C:20]([CH:40]=[CH:39][CH:38]=2)[O:19][CH2:18][C:17]([O:16][CH3:15])=[O:41])[C:25]([CH3:37])=[C:26]3[CH3:36])=[O:34])[CH3:13])=[CH:10][CH:11]=1)([CH3:5])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 71075704HCID 71075704, compoundHCID 122163155Benzenemethanamine, 4-(1,1-dimethylethyl)-α-methyl-, hydrochloride (1:1), (αS)-

Product 1

HCID 71075180HCID 71075180, compound

Procedure

The title compound was prepared following the same protocol as described in Step 5, Example 36, using the (S)-1-(4-(tert-butyl)phenyl)ethanamine hydrochloride instead of the (S)-1-(3-cyclopropylphenyl)ethanamine hydrochloride and the 1-(3-(2-methoxy-2-oxoethoxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid instead of the 1-(4-(2-methoxy-2-oxoethoxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid.

Sources & evidence

ORD record
ord-ac82fe2cbc394b30ba36b1e32f51266d
Source dataset
uspto-grants-2015_06
Patent number
US09051265B2

Reaction notes

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