HCID 71075254, compound → HCID 71075140, compound

HRID 2170634Notes

Reaction equation

HRID 2170634 reaction equation
Cl.[C:2]([C:6]1[CH:11]=[CH:10][C:9]([C@@H:12]([NH2:14])[CH3:13])=[CH:8][CH:7]=1)([CH3:5])([CH3:4])[CH3:3].[CH3:15][O:16][C:17](=[O:42])[C@H:18]([O:20][C:21]1[CH:22]=[C:23]([CH:39]=[CH:40][CH:41]=1)[CH2:24][N:25]1[C:33]2[C:28](=[CH:29][C:30]([C:34](O)=[O:35])=[CH:31][CH:32]=2)[C:27]([CH3:37])=[C:26]1[CH3:38])[CH3:19]>>[C:2]([C:6]1[CH:7]=[CH:8][C:9]([C@@H:12]([NH:14][C:34]([C:30]2[CH:29]=[C:28]3[C:33](=[CH:32][CH:31]=2)[N:25]([CH2:24][C:23]2[CH:22]=[C:21]([CH:41]=[CH:40][CH:39]=2)[O:20][C@H:18]([CH3:19])[C:17]([O:16][CH3:15])=[O:42])[C:26]([CH3:38])=[C:27]3[CH3:37])=[O:35])[CH3:13])=[CH:10][CH:11]=1)([CH3:5])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 71075254HCID 71075254, compoundHCID 122163155Benzenemethanamine, 4-(1,1-dimethylethyl)-α-methyl-, hydrochloride (1:1), (αS)-

Product 1

HCID 71075140HCID 71075140, compound

Procedure

The title compound was prepared following the same protocol as described in Step 5, Example 36, using the (S)-1-(4-(tert-butyl)phenyl)ethanamine hydrochloride instead of the (S)-1-(3-cyclopropylphenyl)ethanamine hydrochloride and the (R)-1-(3-((1-methoxy-1-oxopropan-2-yl)oxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid instead of the 1-(4-(2-methoxy-2-oxoethoxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid.

Sources & evidence

ORD record
ord-8af903320dac46c3bf5c55c61f8e7f35
Source dataset
uspto-grants-2015_06
Patent number
US09051265B2

Reaction notes

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