HCID 71075220, compound → HCID 71075380, compound

HRID 2170635Notes

Reaction equation

HRID 2170635 reaction equation
Cl.[CH:2]([C:5]1[CH:6]=[C:7]([C@@H:11]([NH2:13])[CH3:12])[CH:8]=[CH:9][CH:10]=1)([CH3:4])[CH3:3].[CH3:14][O:15][C:16](=[O:41])[C@@H:17]([O:19][C:20]1[CH:21]=[C:22]([CH:38]=[CH:39][CH:40]=1)[CH2:23][N:24]1[C:32]2[C:27](=[CH:28][C:29]([C:33](O)=[O:34])=[CH:30][CH:31]=2)[C:26]([CH3:36])=[C:25]1[CH3:37])[CH3:18]>>[CH:2]([C:5]1[CH:6]=[C:7]([C@@H:11]([NH:13][C:33]([C:29]2[CH:28]=[C:27]3[C:32](=[CH:31][CH:30]=2)[N:24]([CH2:23][C:22]2[CH:21]=[C:20]([CH:40]=[CH:39][CH:38]=2)[O:19][C@@H:17]([CH3:18])[C:16]([O:15][CH3:14])=[O:41])[C:25]([CH3:37])=[C:26]3[CH3:36])=[O:34])[CH3:12])[CH:8]=[CH:9][CH:10]=1)([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 71075220HCID 71075220, compoundHCID 86674569HCID 86674569, compound

Product 1

HCID 71075380HCID 71075380, compound

Procedure

The title compound was prepared following the same protocol as described in Step 5, Example 36, using the (S)-1-(3-isopropylphenyl)ethanamine hydrochloride instead of the (S)-1-(3-cyclopropylphenyl)ethanamine hydrochloride and the (S)-1-(3-((1-methoxy-1-oxopropan-2-yl)oxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid instead of the 1-(4-(2-methoxy-2-oxoethoxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid.

Sources & evidence

ORD record
ord-4b8fa797a975425d8c9a35c82c490b94
Source dataset
uspto-grants-2015_06
Patent number
US09051265B2

Reaction notes

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