HCID 71075349, compound → HCID 71075504, compound

HRID 2170638Notes

Reaction equation

HRID 2170638 reaction equation
Cl.[C:2]([C:6]1[CH:11]=[CH:10][C:9]([C@@H:12]([NH2:14])[CH3:13])=[CH:8][CH:7]=1)([CH3:5])([CH3:4])[CH3:3].[CH3:15][O:16][C:17](=[O:43])[C:18]([O:21][C:22]1[CH:23]=[C:24]([CH:40]=[CH:41][CH:42]=1)[CH2:25][N:26]1[C:34]2[C:29](=[CH:30][C:31]([C:35](O)=[O:36])=[CH:32][CH:33]=2)[C:28]([CH3:38])=[C:27]1[CH3:39])([CH3:20])[CH3:19]>>[C:2]([C:6]1[CH:7]=[CH:8][C:9]([C@@H:12]([NH:14][C:35]([C:31]2[CH:30]=[C:29]3[C:34](=[CH:33][CH:32]=2)[N:26]([CH2:25][C:24]2[CH:23]=[C:22]([CH:42]=[CH:41][CH:40]=2)[O:21][C:18]([CH3:19])([CH3:20])[C:17]([O:16][CH3:15])=[O:43])[C:27]([CH3:39])=[C:28]3[CH3:38])=[O:36])[CH3:13])=[CH:10][CH:11]=1)([CH3:5])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 71075349HCID 71075349, compoundHCID 122163155Benzenemethanamine, 4-(1,1-dimethylethyl)-α-methyl-, hydrochloride (1:1), (αS)-

Product 1

HCID 71075504HCID 71075504, compound

Procedure

The title compound was prepared following the same protocol as described in Step 5, Example 36, using the (S)-1-(4-(tert-butyl)phenyl)ethanamine hydrochloride instead of the (S)-1-(3-cyclopropylphenyl)ethanamine hydrochloride and the 1-(3-((1-methoxy-2-methyl-1-oxopropan-2-yl)oxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid instead of the 1-(4-(2-methoxy-2-oxoethoxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid.

Sources & evidence

ORD record
ord-6695da21cdc24ac7af14956d7b3763ba
Source dataset
uspto-grants-2015_06
Patent number
US09051265B2

Reaction notes

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