HCID 71075529, compound → HCID 71075282, compound

HRID 2170640Notes

Reaction equation

Cl.[CH:2]([C:5]1[CH:6]=[C:7]([C@@H:11]([NH2:13])[CH3:12])[CH:8]=[CH:9][CH:10]=1)([CH3:4])[CH3:3].[C:14]([CH2:16][O:17][C:18]1[CH:19]=[C:20]([CH:36]=[CH:37][CH:38]=1)[CH2:21][N:22]1[C:30]2[C:25](=[CH:26][C:27]([C:31](O)=[O:32])=[CH:28][CH:29]=2)[C:24]([CH3:34])=[C:23]1[CH3:35])#[N:15]>>[C:14]([CH2:16][O:17][C:18]1[CH:19]=[C:20]([CH:36]=[CH:37][CH:38]=1)[CH2:21][N:22]1[C:30]2[C:25](=[CH:26][C:27]([C:31]([NH:13][C@H:11]([C:7]3[CH:8]=[CH:9][CH:10]=[C:5]([CH:2]([CH3:4])[CH3:3])[CH:6]=3)[CH3:12])=[O:32])=[CH:28][CH:29]=2)[C:24]([CH3:34])=[C:23]1[CH3:35])#[N:15]

Participants

Reactant 2

HCID 71075529HCID 71075529, compound

HCID 86674569HCID 86674569, compound

Product 1

HCID 71075282HCID 71075282, compound

Procedure

The title compound was prepared following the same protocol as described in Step 5, Example 36, using the (S)-1-(3-isopropylphenyl)ethanamine hydrochloride instead of the (S)-1-(3-cyclopropylphenyl)ethanamine hydrochloride and the 1-(3-(cyanomethoxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid instead of the 1-(4-(2-methoxy-2-oxoethoxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid. ESI-MS (m/z): 480 [M+H]+.

Sources & evidence

ORD record: ord-8a18b8ffb56944a9971f395bfa8f345e
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09051265B2

Reaction notes

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