HCID 71075529, compound → HCID 71075706, compound

HRID 2170641Notes

Reaction equation

HRID 2170641 reaction equation
Cl.[C:2]([C:6]1[CH:11]=[CH:10][C:9]([C@@H:12]([NH2:14])[CH3:13])=[CH:8][CH:7]=1)([CH3:5])([CH3:4])[CH3:3].[C:15]([CH2:17][O:18][C:19]1[CH:20]=[C:21]([CH:37]=[CH:38][CH:39]=1)[CH2:22][N:23]1[C:31]2[C:26](=[CH:27][C:28]([C:32](O)=[O:33])=[CH:29][CH:30]=2)[C:25]([CH3:35])=[C:24]1[CH3:36])#[N:16]>>[C:2]([C:6]1[CH:7]=[CH:8][C:9]([C@@H:12]([NH:14][C:32]([C:28]2[CH:27]=[C:26]3[C:31](=[CH:30][CH:29]=2)[N:23]([CH2:22][C:21]2[CH:37]=[CH:38][CH:39]=[C:19]([O:18][CH2:17][C:15]#[N:16])[CH:20]=2)[C:24]([CH3:36])=[C:25]3[CH3:35])=[O:33])[CH3:13])=[CH:10][CH:11]=1)([CH3:5])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 71075529HCID 71075529, compoundHCID 122163155Benzenemethanamine, 4-(1,1-dimethylethyl)-α-methyl-, hydrochloride (1:1), (αS)-

Product 1

HCID 71075706HCID 71075706, compound

Procedure

The title compound was prepared following the same protocol as described in Step 5, Example 36, using the (S)-1-(4-(tert-butyl)phenyl)ethanamine hydrochloride instead of the (S)-1-(3-cyclopropylphenyl)ethanamine hydrochloride and the 1-(3-(cyanomethoxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid instead of the 1-(4-(2-methoxy-2-oxoethoxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid. ESI-MS (m/z): 494 [M+H]+.

Sources & evidence

ORD record
ord-90cb8e6007ff477a9c017c6e727157b2
Source dataset
uspto-grants-2015_06
Patent number
US09051265B2

Reaction notes

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