HCID 71075253, compound → HCID 71075791, compound

HRID 2170643Notes

Reaction equation

HRID 2170643 reaction equation
Cl.[CH:2]([C:5]1[CH:6]=[C:7]([C@@H:11]([NH2:13])[CH3:12])[CH:8]=[CH:9][CH:10]=1)([CH3:4])[CH3:3].[CH3:14][O:15][C:16](=[O:41])[C@@H:17]([O:19][C:20]1[CH:40]=[CH:39][C:23]([CH2:24][N:25]2[C:33]3[C:28](=[CH:29][C:30]([C:34](O)=[O:35])=[CH:31][CH:32]=3)[C:27]([CH3:37])=[C:26]2[CH3:38])=[CH:22][CH:21]=1)[CH3:18]>>[CH:2]([C:5]1[CH:6]=[C:7]([C@@H:11]([NH:13][C:34]([C:30]2[CH:29]=[C:28]3[C:33](=[CH:32][CH:31]=2)[N:25]([CH2:24][C:23]2[CH:39]=[CH:40][C:20]([O:19][C@@H:17]([CH3:18])[C:16]([O:15][CH3:14])=[O:41])=[CH:21][CH:22]=2)[C:26]([CH3:38])=[C:27]3[CH3:37])=[O:35])[CH3:12])[CH:8]=[CH:9][CH:10]=1)([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 71075253HCID 71075253, compoundHCID 86674569HCID 86674569, compound

Product 1

HCID 71075791HCID 71075791, compound

Procedure

The title compound was prepared following the same protocol as described in Step 5, Example 36, using the (S)-1-(3-isopropylphenyl)ethanamine hydrochloride instead of the (S)-1-(3-cyclopropylphenyl)ethanamine hydrochloride and the (S)-1-(4-((1-methoxy-1-oxopropan-2-yl)oxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid instead of the 1-(4-(2-methoxy-2-oxoethoxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid.

Sources & evidence

ORD record
ord-ae166daab00e4768bb07ffdf2598f35b
Source dataset
uspto-grants-2015_06
Patent number
US09051265B2

Reaction notes

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