HCID 71075540, compound → HCID 71075807, compound

HRID 2170645Notes

Reaction equation

Cl.[CH:2]([C:5]1[CH:6]=[C:7]([C@@H:11]([NH2:13])[CH3:12])[CH:8]=[CH:9][CH:10]=1)([CH3:4])[CH3:3].[CH3:14][O:15][C:16](=[O:42])[C:17]([O:20][C:21]1[CH:41]=[CH:40][C:24]([CH2:25][N:26]2[C:34]3[C:29](=[CH:30][C:31]([C:35](O)=[O:36])=[CH:32][CH:33]=3)[C:28]([CH3:38])=[C:27]2[CH3:39])=[CH:23][CH:22]=1)([CH3:19])[CH3:18]>>[CH:2]([C:5]1[CH:6]=[C:7]([C@@H:11]([NH:13][C:35]([C:31]2[CH:30]=[C:29]3[C:34](=[CH:33][CH:32]=2)[N:26]([CH2:25][C:24]2[CH:40]=[CH:41][C:21]([O:20][C:17]([CH3:19])([CH3:18])[C:16]([O:15][CH3:14])=[O:42])=[CH:22][CH:23]=2)[C:27]([CH3:39])=[C:28]3[CH3:38])=[O:36])[CH3:12])[CH:8]=[CH:9][CH:10]=1)([CH3:4])[CH3:3]

Participants

Reactant 2

HCID 71075540HCID 71075540, compound

HCID 86674569HCID 86674569, compound

Product 1

HCID 71075807HCID 71075807, compound

Procedure

The title compound was prepared following the same protocol as described in Step 5, Example 36, using the (S)-1-(3-isopropylphenyl)ethanamine hydrochloride instead of the (S)-1-(3-cyclopropylphenyl)ethanamine hydrochloride and the 1-(4-((1-methoxy-2-methyl-1-oxopropan-2-yl)oxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid instead of the 1-(4-(2-methoxy-2-oxoethoxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid.

Sources & evidence

ORD record: ord-12a13dcded5546a7a952ac0ade9b5726
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09051265B2

Reaction notes

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