HCID 86674584, compound → HCID 86674585, compound

HRID 2170648Notes

Reaction equation

HRID 2170648 reaction equation
Cl[C:2]1[CH:25]=[CH:24][C:23]([O:26][C@@H:27]([CH3:32])[C:28]([O:30][CH3:31])=[O:29])=[CH:22][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([C:14]([O:16][CH2:17][CH:18]=[CH2:19])=[O:15])=[CH:11][CH:12]=2)[C:7]([CH3:20])=[C:6]1[CH3:21].BrCC1C=CC([Cl:48])=C(C=1)O[C@@H](C)C(OC)=O>>[Cl:48][C:24]1[CH:25]=[CH:2][C:3]([CH2:4][N:5]2[C:13]3[C:8](=[CH:9][C:10]([C:14]([O:16][CH2:17][CH:18]=[CH2:19])=[O:15])=[CH:11][CH:12]=3)[C:7]([CH3:20])=[C:6]2[CH3:21])=[CH:22][C:23]=1[O:26][C@@H:27]([CH3:32])[C:28]([O:30][CH3:31])=[O:29]

Participants

3

Reactant 2

HCID 86674584HCID 86674584, compoundHCID 86674586HCID 86674586, compound

Product 1

HCID 86674585HCID 86674585, compound

Procedure

The title compound was prepared following the same general protocol as described for the synthesis of the (S)-allyl 1-(2-chloro-5-((1-methoxy-1-oxopropan-2-yl)oxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylate (Step 3, Example 26), using the (S)-methyl 2-(5-(bromomethyl)-2-chlorophenoxy)propanoate instead of the (S)-methyl 2-(3-(bromomethyl)-4-chlorophenoxy)propanoate ESI-MS (m/z): 456 [M+1]+.

Sources & evidence

ORD record
ord-63a49b5c68d44418a7222a7b2707731f
Source dataset
uspto-grants-2015_06
Patent number
US09051265B2

Reaction notes

Loading…