HCID 71075618, compound → HCID 71075300, compound

HRID 2170649Notes

Reaction equation

ClC1C=CC(O[C@@H](C)C(OC)=O)=CC=1CN1C2C(=CC(C(O)=O)=CC=2)C(C)=C1C.[Cl:30][C:31]1[CH:54]=[CH:53][C:34]([CH2:35][N:36]2[C:44]3[C:39](=[CH:40][C:41]([C:45]([O:47]CC=C)=[O:46])=[CH:42][CH:43]=3)[C:38]([CH3:51])=[C:37]2[CH3:52])=[CH:33][C:32]=1[O:55][C@@H:56]([CH3:61])[C:57]([O:59][CH3:60])=[O:58]>>[Cl:30][C:31]1[CH:54]=[CH:53][C:34]([CH2:35][N:36]2[C:44]3[C:39](=[CH:40][C:41]([C:45]([OH:47])=[O:46])=[CH:42][CH:43]=3)[C:38]([CH3:51])=[C:37]2[CH3:52])=[CH:33][C:32]=1[O:55][C@@H:56]([CH3:61])[C:57]([O:59][CH3:60])=[O:58]

Participants

Reactant 2

HCID 71075618HCID 71075618, compound

HCID 86674585HCID 86674585, compound

Product 1

HCID 71075300HCID 71075300, compound

Procedure

The title compound was prepared following the same general protocol as described for the synthesis of the (S)-1-(2-chloro-5-((1-methoxy-1-oxopropan-2-yl)oxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid (Step 4, Example 26), using the (S)-allyl 1-(4-chloro-3-((1-methoxy-1-oxopropan-2-yl)oxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylate instead of the (S)-allyl 1-(2-chloro-5-((1-methoxy-1-oxopropan-2-yl)oxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylate.

Sources & evidence

ORD record: ord-025c93e420ad4f4f9ae160615049cca9
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09051265B2

Reaction notes

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