(S)-1-(4-tert-butylphenyl)ethanamine → HCID 71075736, compound

HRID 2170714Notes

Reaction equation

HRID 2170714 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C@@H:11]([NH2:13])[CH3:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:14][O:15][C:16](=[O:42])[C@@H:17]([O:19][C:20]1[CH:25]=[CH:24][C:23]([CH:26]([N:28]2[C:36]3[C:31](=[CH:32][C:33]([C:37](O)=[O:38])=[CH:34][CH:35]=3)[C:30]([CH3:40])=[C:29]2[CH3:41])[CH3:27])=[CH:22][CH:21]=1)[CH3:18]>>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([C@@H:11]([NH:13][C:37]([C:33]2[CH:32]=[C:31]3[C:36](=[CH:35][CH:34]=2)[N:28]([CH:26]([C:23]2[CH:24]=[CH:25][C:20]([O:19][C@@H:17]([CH3:18])[C:16]([O:15][CH3:14])=[O:42])=[CH:21][CH:22]=2)[CH3:27])[C:29]([CH3:41])=[C:30]3[CH3:40])=[O:38])[CH3:12])=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 7026229(S)-1-(4-tert-butylphenyl)ethanamineHCID 71075085HCID 71075085, compound

Product 1

HCID 71075736HCID 71075736, compound

Procedure

The title compound was prepared following the same general protocol as described in Step 5, Example 35, using (S)-1-(4-(tert-butyl)phenyl)ethanamine instead of (S)-1-(3-bromophenyl)ethylamine and 1-(1-(4-(((S)-1-methoxy-1-oxopropan-2-yl)oxy)phenyl)ethyl)-2,3-dimethyl-1H-indole-5-carboxylic acid instead of 1-(4-(1-(methoxycarbonyl)cyclopropyl)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid′

Sources & evidence

ORD record
ord-71a8f2a3632a4c838859bb2eb35e2a89
Source dataset
uspto-grants-2015_06
Patent number
US09051265B2

Reaction notes

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