反应详情

温度

230 °C

To a solution of 3-[2-(4-Chloro-phenyl)-thiazol-5-ylmethoxy]-cyclopent-2-enone (1.29 g, 4.22 mmol) in ethylene glycol dimethyl ether (10 ml) was added 1-butyl-3-methylimidazolium bis(trifluoromethylsulphonyl)imide (100 μl) and the reaction heated to 230° C. by microwave irradiation for 30 minutes. The crude reaction mixture was dry loaded onto silica and purified by flash chromatography to give 2-[2-(4-Chloro-phenyl)-5-methyl-thiazol-4-yl]-cyclopentane-1,3-dione (1.12 g).

1. customThe crude reaction mixture
2. customwas dry
3. custompurified by flash chromatography