HCID 66926165, compound → HCID 66926115, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-[2-(4-Chloro-phenyl)-5-methyl-thiazol-4-yl]-4-[1-(5-fluoro-pyridin-2-yl)-meth-(E)-ylidene]-cyclopentane-1,3-dione (70 mg, 0.17 mmol) in glacial acetic acid (2 ml) was added zinc powder (10 mg), and the reaction heated to 80° C. for 17 hours. The crude reaction mixture was then dry loaded onto silica and purified by flash chromatography to give 2-[2-(4-Chloro-phenyl)-5-methyl-thiazol-4-yl]-4-(5-fluoro-pyridin-2-ylmethyl)-cyclopentane-1,3-dione (55 mg).

Provenance & Evidence