HCID 66926134, compound → HCID 66925814, compound

Participants

Reaction Steps

To a solution of 2-[5-(4-Chloro-phenyl)-2-methyl-thiophen-3-yl]-4-[1-(tetrahydro-pyran-4-yl)-meth-(E)-ylidene]-cyclopentane-1,3-dione (88 mg, 0.22 mmol) in ethanol (2 ml) was added 5% palladium on carbon (9 mg) and the reaction stirred under an atmosphere of hydrogen at a pressure of 2 bar for 4 hours. The crude reaction mixture was filtered through a pad of Celite and purified by preparative mass-directed HPLC to give 2-[5-(4-Chloro-phenyl)-2-methyl-thiophen-3-yl]-4-(tetrahydro-pyran-4-ylmethyl)-cyclopentane-1,3-dione (43 mg).

Provenance & Evidence