Hydrogen chloride-ethyl acetate → HCID 67169066, compound

HRID 2170841Notes

Reaction equation

HRID 2170841 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([CH:21]=[CH:22][CH:23]=1)[O:7][CH:8]1[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]1)(=[O:3])[CH3:2].C(OC(=O)C)C.[ClH:30]>>[ClH:30].[NH:11]1[CH2:10][CH2:9][CH:8]([O:7][C:6]2[CH:5]=[C:4]([C:1](=[O:3])[CH3:2])[CH:23]=[CH:22][CH:21]=2)[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86670542HCID 86670542, compound

Product 1

HCID 67169066HCID 67169066, compoundYield 89%

Procedure

tert-Butyl 4-(3-acetylphenoxy)piperidine-1-carboxylate (4.70 g, 14.7 mmol, Step-1) was dissolved in 4M hydrochloric acid ethyl acetate solution (30 mL). The mixture was stirred at room temperature for 2 hours. After concentration under reduced pressure, the residue was crystallized from diisopropylether to give 3.37 g (89%) of the title compound as a white solid.

Workup

  1. concentrationAfter concentration under reduced pressure
  2. customthe residue was crystallized from diisopropylether

Sources & evidence

ORD record
ord-5ccfde1552004a3391f548dc714612d0
Source dataset
uspto-grants-2015_06
Patent number
US09051296B2

Reaction notes

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