Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1H-Indole-5-carboxylic acid, 1-(2-methoxyethyl)-, methyl ester | HCID 67169484 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1304787-76-5 | HCID 63750378 | 95% |
Reaction Steps
A mixture of methyl 1-(2-methoxyethyl)-1H-indole-5-carboxylate (132 mg, 0.57 mmol, Step-1), 2M aqueous sodium hydroxide solution (2 mL), and methanol (2 mL) was stirred at 60° C. for 2 hours. The mixture was acidified with 2M aqueous hydrochloric acid solution, and the organic solvent was concentrated under reduced pressure. The precipitate was collected by filtration and dried to give 118 mg (95%) of the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09051296B2 |
|---|
| Source dataset | uspto-grants-2015_06 |
|---|
| ORD ID | ord-9d1f213d501747d5a0db55da64284643 |
|---|
| Source note | uspto-grants-2015_06 |
|---|
