(2-Methoxyethyl)(methyl)amine → HCID 67169499, compound

HRID 2170866Notes

Reaction equation

HRID 2170866 reaction equation
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([O:6][CH:7]2[CH2:12][CH2:11][N:10]([C:13]([C:15]3[CH:23]=[CH:22][C:18]([C:19]([OH:21])=O)=[CH:17][CH:16]=3)=[O:14])[CH2:9][CH2:8]2)=[CH:4][CH:3]=1.[CH3:26][O:27][CH2:28][CH2:29][NH:30][CH3:31]>>[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([O:6][CH:7]2[CH2:12][CH2:11][N:10]([C:13]([C:15]3[CH:23]=[CH:22][C:18]([C:19]([N:30]([CH2:29][CH2:28][O:27][CH3:26])[CH3:31])=[O:21])=[CH:17][CH:16]=3)=[O:14])[CH2:9][CH2:8]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 300977(2-Methoxyethyl)(methyl)amineHCID 67168371HCID 67168371, compound

Product 1

HCID 67169499HCID 67169499, compoundYield 51%

Procedure

The title compound was prepared in 51% yield (10.1 mg) prepared from 4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)benzoic acid (Step-2) according to the procedure similar to that described in Step-2 of Example 349, using 2-methoxy-N-methylethanamine instead of 25% ammonium water.

Sources & evidence

ORD record
ord-a77cd2f88e6e4c26b0457e1a41bb7a82
Source dataset
uspto-grants-2015_06
Patent number
US09051296B2

Reaction notes

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