2-(4-Fluoro-3-phenyl-1H-pyrazol-1-yl)nicotinic acid → Ethyl 3-(2-(4-fluoro-3-phenyl-1H-pyrazol-1-yl)nicotinamido)-2-hydroxy-4-phenylbutanoate

HRID 2170876Notes

Reaction equation

HRID 2170876 reaction equation
[F:1][C:2]1[C:3]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[N:4][N:5]([C:7]2[N:15]=[CH:14][CH:13]=[CH:12][C:8]=2[C:9]([OH:11])=O)[CH:6]=1.[Cl-].[CH2:23]([O:25][C:26](=[O:38])[CH:27]([OH:37])[CH:28]([NH3+:36])[CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH3:24]>>[F:1][C:2]1[C:3]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[N:4][N:5]([C:7]2[N:15]=[CH:14][CH:13]=[CH:12][C:8]=2[C:9]([NH:36][CH:28]([CH2:29][C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:27]([OH:37])[C:26]([O:25][CH2:23][CH3:24])=[O:38])=[O:11])[CH:6]=1

Participants

3

Reactant 2

HCID 672390012-(4-Fluoro-3-phenyl-1H-pyrazol-1-yl)nicotinic acidHCID 86644788HCID 86644788, compound

Product 1

HCID 67241588Ethyl 3-(2-(4-fluoro-3-phenyl-1H-pyrazol-1-yl)nicotinamido)-2-hydroxy-4-phenylbutanoate

Procedure

The reaction was carried out in analogy to reaction step 1.1 by reacting 2-(4-fluoro-3-phenyl-1H-pyrazol-1-yl)nicotinic acid and 4-ethoxy-3-hydroxy-4-oxo-1-phenylbutan-2-aminium chloride. ESI-MS [M+H]+: 489.2

Workup

  1. customThe reaction was carried out in analogy to reaction step 1.1

Sources & evidence

ORD record
ord-7d1808585b8d4580b70ca4906cb5d980
Source dataset
uspto-grants-2015_06
Patent number
US09051304B2

Reaction notes

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