O-Allylhydroxylamine hydrochloride → HCID 86654649, compound

HRID 2170884Notes

Reaction equation

HRID 2170884 reaction equation
[OH:1][CH:2]([CH:6]([NH:14][C:15](=[O:33])[C:16]1[CH:21]=[CH:20][CH:19]=[N:18][C:17]=1[N:22]1[CH:26]=[CH:25][C:24]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[N:23]1)[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:3]([OH:5])=O.Cl.[CH2:35]([O:38][NH2:39])[CH:36]=[CH2:37]>>[CH2:35]([O:38][NH:39][C:3](=[O:5])[CH:2]([OH:1])[CH:6]([NH:14][C:15](=[O:33])[C:16]1[CH:21]=[CH:20][CH:19]=[N:18][C:17]=1[N:22]1[CH:26]=[CH:25][C:24]([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)=[N:23]1)[CH2:7][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[CH:36]=[CH2:37]

Participants

3

Reactant 2

HCID 3084724O-Allylhydroxylamine hydrochlorideHCID 672381942-hydroxy-4-phenyl-3-(2-(3-phenyl-1H-pyrazol-1-yl)nicotinamido)butanoic acid

Product 1

HCID 86654649HCID 86654649, compound

Procedure

The reaction was carried out in analogy to reaction step 1.3 by reacting 2-hydroxy-4-phenyl-3-(2-(3-phenyl-1H-pyrazol-1-yl)nicotinamido)butanoic acid with O-allylhydroxylamine hydrochloride. ESI-MS [M+H]+: 498.2

Workup

  1. customThe reaction was carried out in analogy to reaction step 1.3

Sources & evidence

ORD record
ord-76f2801352294c99a522df48d054e012
Source dataset
uspto-grants-2015_06
Patent number
US09051304B2

Reaction notes

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