O-Methylhydroxylamine → HCID 86652465, compound

HRID 2170898Notes

Reaction equation

HRID 2170898 reaction equation
[F:1][C:2]1[CH:30]=[CH:29][CH:28]=[CH:27][C:3]=1[CH2:4][N:5]1[C:9](=[O:10])[CH2:8][CH2:7][C@@H:6]1[C:11]([NH:13][CH:14]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH:15]([OH:19])[C:16](O)=[O:17])=[O:12].[CH3:31][O:32][NH2:33]>>[F:1][C:2]1[CH:30]=[CH:29][CH:28]=[CH:27][C:3]=1[CH2:4][N:5]1[C:9](=[O:10])[CH2:8][CH2:7][C@@H:6]1[C:11]([NH:13][CH:14]([CH:15]([OH:19])[C:16]([NH:33][O:32][CH3:31])=[O:17])[CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:12]

Participants

3

Reactant 2

HCID 4113O-MethylhydroxylamineHCID 67094830HCID 67094830, compound

Product 1

HCID 86652465HCID 86652465, compound

Procedure

The reaction can be carried out in analogy to reaction step 1.3 by reacting 3-((R)-1-(2-fluorobenzyl)-5-oxopyrrolidine-2-carboxamido)-2-hydroxy-4-phenylbutanoic acid with O-methylhydroxylamine.

Workup

  1. customThe reaction
  2. customcan be carried out in analogy to reaction step 1.3

Sources & evidence

ORD record
ord-2718288695d54063b472f79562e5fa47
Source dataset
uspto-grants-2015_06
Patent number
US09051304B2

Reaction notes

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