HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 86723574, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 58035649 | HCID 58035649 | — |
| Reactant | HCID 86723572 | HCID 86723572 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86723574 | HCID 86723574 | — |
Reaction Steps
To a mixture of intermediate C.HCl (340 mg, 1.2 mmol), intermediate A (261 mg, 1.26 mmol), HATU (638 mg, 1.68 mmol), and N-methyl morpholine (330 μL, 3.00 mmol) was added DMF (5 mL) and the reaction was stirred for 2 hours. The mixture was concentrated, redissolved in a minimal amount of CH3CN, and water was added dropwise until a thick slurry was formed. The solids were isolated by filtration and washed with CH3CN to afford 320 mg (61% y). M+1=437.2
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09051313B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-00404046af67475a8f727e6821f175e8 |
| Source note | uspto-grants-2015_06 |