Hydrochloric Acid → {(S)-6-[(R)-4-bromo-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

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Reaction Steps

5.87 g (11.9 mmol) [(S)-6-((R)-4-bromo-7-fluoroindan-1-yloxy)-2,3-dihydrobenzo-furan-3-yl]-acetic acid morpholine salt is suspended in 22 ml MeOH. Then, 3.56 ml (14.2 mmol) HCl (4 M in dioxane) is added and the funnel is rinsed with 1.50 ml MeOH. The mixture is stirred overnight at r.t. and seeds are added. After 30 min, 5.90 ml water is added and stirring is continued. The precipitated product is filtered off, washed with 14.6 ml MeOH/water (4:1) and dried. Yield: 4.25 g; Rf=0.39 (silica gel, PE/EtOAc=8/2); Mass spectrum (ESI): m/z=421 [M+H]+.

Provenance & Evidence