Ethyl orthoformate → HCID 68602981, compound

Participants

Reaction Conditions

Reaction Steps

1.20 g (2.78 mmol) of the compound from Example 39A and 9.25 ml (55.6 mmol) of triethyl orthoformate are taken up in 30 ml of dry DMF and heated to 130° C., and 5 drops of concentrated sulfuric acid are added. After 2 h, an HPLC check shows complete conversion. After cooling, the volatile components are removed in a rotary evaporator, and the crude product is purified by MPLC (Biotage cartridge 40 M, eluent: isohexane/ethyl acetate 1:2). 640 mg (50% of theory) of the title compound are obtained.

Provenance & Evidence