Ammonia → HCID 24993043, compound

Participants

Reaction Conditions

Reaction Steps

100 mg (approx. 0.24 mmol) of the compound from Example 23A are introduced into 3 ml of DMF. Then 2.94 mg (0.024 mmol) of 4-N,N-dimethylaminopyridine and 340 μl of ammonia (28% by weight solution in water, 2.41 mmol) are added, and the mixture is heated at 100° C. for 3 h. After cooling, the crude product is directly purified by preparative HPLC (eluent: acetonitrile/water with 0.1% formic acid, gradient 20:80→95:5). 32 mg (37% of theory) of the title compound are obtained.

Provenance & Evidence