HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2170988Generated: November 1, 2026
1,1'-Carbonyldiimidazole → 1-Cyclopropyl-1,3-dihydroimidazo[4,5-c]pyridine-2-one
https://huagongshe.com/reaction/2170988
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 4-N-cyclopropylpyridine-3,4-diamine | HCID 19102553 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-Cyclopropyl-1,3-dihydroimidazo[4,5-c]pyridine-2-one | HCID 22349361 | — |
Reaction Steps
CDI (CAS 530-62-1) (151.8 g, 936 mmol) was added to a solution of the intermediate 5-c (133 g, 891.4 mmol) in CH3CN (1800 mL) at 0° C. The reaction was allowed to warm to 10° C. and stirred for 1 hour. The solid was collected by filtration, then washed with CH3CN (200 mL) to afford compound 5-d as a white powder (101 g, 65%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09051317B2 |
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| Source dataset | uspto-grants-2015_06 |
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| ORD ID | ord-108a75d0fb2f45deb0c7f1b7f017c589 |
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| Source note | uspto-grants-2015_06 |
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