HCID 67463920, compound → HCID 54577378, compound

HRID 2171045Notes

Reaction equation

HRID 2171045 reaction equation
[CH3:1][O:2][C:3]1[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[C:13]([C:19]2[CH:27]=[CH:26][CH:25]=[C:24]3[C:20]=2[CH2:21][CH2:22][C:23]3=[O:28])[C:4]=1[O:5][CH2:6][C:7]([CH3:12])([CH3:11])[C:8](O)=[O:9].COC1C(OC)=CC=C(C2C=CC=C3C=2CCC3=O)C=1OC[C:35](C)(C)[C:36]([NH:38]C)=O>>[CH3:1][O:2][C:3]1[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[C:13]([C:19]2[CH:27]=[CH:26][CH:25]=[C:24]3[C:20]=2[CH2:21][CH2:22][C:23]3=[O:28])[C:4]=1[O:5][CH2:6][C:7]([CH3:12])([CH3:11])[C:8]([NH:38][CH2:36][CH3:35])=[O:9]

Participants

3

Reactant 2

HCID 67463920HCID 67463920, compoundHCID 67466830HCID 67466830, compound2×

Product 1

HCID 54577378HCID 54577378, compound

Procedure

From 3-[2,3-Dimethoxy-6-(1-oxo-indan-4-yl)-phenoxy]-2,2-dimethyl-propionic acid (Compound 199) and 2-Methylamine solution following the procedure for the preparation of Compound 200. Purification by column chromatography (silica gel, 0-50% ethyl acetate in pet ether) afforded the title compound as a solid.

Workup

  1. customPurification by column chromatography (silica gel, 0-50% ethyl acetate in pet ether)

Sources & evidence

ORD record
ord-274e72bab29649ce98de69ae525176db
Source dataset
uspto-grants-2015_06
Patent number
US09051290B2

Reaction notes

Loading…