Cyclopropylamine → HCID 67466577, compound

HRID 2171047Notes

Reaction equation

HRID 2171047 reaction equation
[CH3:1][O:2][C:3]1[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[C:13]([C:19]2[CH:27]=[CH:26][CH:25]=[C:24]3[C:20]=2[CH2:21][CH2:22][C:23]3=[O:28])[C:4]=1[O:5][CH2:6][C:7]([CH3:12])([CH3:11])[C:8](O)=[O:9].[CH:29]1([NH2:32])[CH2:31][CH2:30]1.COC1C(OC)=CC=C(C2C=CC=C3C=2CCC3=O)C=1OCC(C)(C)C(NC)=O>>[CH:29]1([NH:32][C:8](=[O:9])[C:7]([CH3:11])([CH3:12])[CH2:6][O:5][C:4]2[C:13]([C:19]3[CH:27]=[CH:26][CH:25]=[C:24]4[C:20]=3[CH2:21][CH2:22][C:23]4=[O:28])=[CH:14][CH:15]=[C:16]([O:17][CH3:18])[C:3]=2[O:2][CH3:1])[CH2:31][CH2:30]1

Participants

4

Reactant 3

HCID 69828CyclopropylamineHCID 67463920HCID 67463920, compoundHCID 67466830HCID 67466830, compound2×

Product 1

HCID 67466577HCID 67466577, compound

Procedure

From 3-[2,3-Dimethoxy-6-(1-oxo-indan-4-yl)-phenoxy]-2,2-dimethyl-propionic acid (Compound 199) and cyclopropylamine following the procedure for the preparation of Compound 200. Purification by column chromatography (silica gel, 0-50% ethyl acetate in pet ether) afforded the title compound as a solid.

Workup

  1. customPurification by column chromatography (silica gel, 0-50% ethyl acetate in pet ether)

Sources & evidence

ORD record
ord-92c27753258145b088b8ff0c4fc89d90
Source dataset
uspto-grants-2015_06
Patent number
US09051290B2

Reaction notes

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