Morpholine → HCID 67463180, compound

HRID 2171048Notes

Reaction equation

HRID 2171048 reaction equation
[CH3:1][O:2][C:3]1[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[C:13]([C:19]2[CH:27]=[CH:26][CH:25]=[C:24]3[C:20]=2[CH2:21][CH2:22][C:23]3=[O:28])[C:4]=1[O:5][CH2:6][C:7]([CH3:12])([CH3:11])[C:8](O)=[O:9].[NH:29]1[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1.COC1C(OC)=CC=C(C2C=CC=C3C=2CCC3=O)C=1OCC(C)(C)C(NC)=O>>[CH3:12][C:7]([CH3:11])([C:8]([N:29]1[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1)=[O:9])[CH2:6][O:5][C:4]1[C:3]([O:2][CH3:1])=[C:16]([O:17][CH3:18])[CH:15]=[CH:14][C:13]=1[C:19]1[CH:27]=[CH:26][CH:25]=[C:24]2[C:20]=1[CH2:21][CH2:22][C:23]2=[O:28]

Participants

4

Reactant 3

HCID 8083MorpholineHCID 67463920HCID 67463920, compoundHCID 67466830HCID 67466830, compound2×

Product 1

HCID 67463180HCID 67463180, compound

Procedure

From 3-[2,3-Dimethoxy-6-(1-oxo-indan-4-yl)-phenoxy]-2,2-dimethyl-propionic acid (Compound 199) and morpholine following the procedure for the preparation of Compound 200. Purification by column chromatography (silica gel, 0-50% ethyl acetate in pet ether) afforded the title compound as a solid.

Workup

  1. customPurification by column chromatography (silica gel, 0-50% ethyl acetate in pet ether)

Sources & evidence

ORD record
ord-968906cbfded4931af35ea395fdd5c4c
Source dataset
uspto-grants-2015_06
Patent number
US09051290B2

Reaction notes

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