HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2171055Generated: November 1, 2026
Water → 4-[3,4-Dimethoxy-2-(3-methoxy-2,2-dimethyl-propoxy)-phenyl]-indan-1-one
https://huagongshe.com/reaction/2171055
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Bromo-3-methoxy-2,2-dimethylpropane | HCID 64995448 | — |
| Reactant | 4-(2-Hydroxy-3,4-dimethoxy-phenyl)-indan-1-one | HCID 67466806 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-[3,4-Dimethoxy-2-(3-methoxy-2,2-dimethyl-propoxy)-phenyl]-indan-1-one | HCID 67467715 | — |
Reaction Steps
Compound 303 (0.02 g, 0.07 mmol) and 1-bromo-3-methoxy-2,2-dimethyl-propane (0.12 g, 0.56 mmol) were dissolved in dry DMF (0.8 mL). K2CO3 (0.1 g, 0.68 mmol) were added. The suspension was heated at 100° C. for 18 h. H2O was added and the mixture was extracted with EtOAc (×2). The combined organic phases were washed with brine, dried (Na2SO4), filtered and concentrated. Purification by preparative HPLC afforded the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09051290B2 |
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| Source dataset | uspto-grants-2015_06 |
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| ORD ID | ord-d03a410ef7f24d4cb26aafa49bfa414f |
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| Source note | uspto-grants-2015_06 |
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