Potassium Carbonate → 4-((6-Bromo-3-(difluoromethoxy)-2-methoxyphenoxy)methyl)benzamide

Participants

Reaction Conditions

Reaction Steps

To a stirring solution of 6-bromo-3-(difluoromethoxy)-2-methoxyphenol (1.0 g, 3.71 mmol) in acetonitrile (10 mL), was added potassium carbonate (1.53 g, 11.08 mmol) and followed by 4-(bromomethyl)benzamide (795 mg, 3.71 mmol) and the resultant reaction mixture was heated to 80° C. for 16 h. The reaction mixture was cooled to RT and filtered through celite and the filtrate was concentrated under reduced pressure to afford 4-((6-Bromo-3-(difluoromethoxy)-2-methoxyphenoxy)methyl)benzamide as a solid (1 g, 67%).

Provenance & Evidence