Hydrochloric Acid → HCID 70170377, compound

Participants

Reaction Conditions

Reaction Steps

To a stirring solution of 5-(4-ethoxy-3-methoxy-2-(methoxymethoxy)phenyl)-2,3-dihydro-1H-inden-1-one (1 g, 2.92 mmol) in methanol (20 mL) was added conc. hydrochloric acid (3 mL) and heated to 60° C. for 1 h. The reaction mixture was cooled to RT and concentrated under reduced pressure. The residue was basified with sodium bicarbonate solution and extracted with ethyl acetate (3×). The combined ethyl acetate layers were washed with brine, dried over sodium sulphate and concentrated under reduced pressure to afford the title compound as a solid (850 mg, 97.7%).

Provenance & Evidence