4-Bromoisoindolin-1-one → 4-(2-Hydroxy-3,4-dimethoxy-phenyl)isoindolin-1-one

HRID 2171212Notes

Reaction equation

HRID 2171212 reaction equation
[OH:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([O:10][CH3:11])[CH:5]=[CH:4][C:3]=1[C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[C:17](=O)[NH:16][CH2:15]2.BrC1C=CC=C2C=1CNC2=[O:32]>>[OH:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([O:10][CH3:11])[CH:5]=[CH:4][C:3]=1[C:12]1[CH:20]=[CH:19][CH:18]=[C:14]2[C:13]=1[CH2:17][NH:16][C:15]2=[O:32]

Participants

3

Reactant 2

HCID 219075094-Bromoisoindolin-1-oneHCID 674639885-(2-Hydroxy-3,4-dimethoxyphenyl)isoindolin-1-one

Product 1

HCID 674629964-(2-Hydroxy-3,4-dimethoxy-phenyl)isoindolin-1-one

Procedure

4-(2-Hydroxy-3,4-dimethoxy-phenyl)isoindolin-1-one is synthesized following the same procedure as the one described for the synthesis of Compound 307 using 4-bromo-2,3-dihydro-1H-isoindol-1-one as starting material.

Sources & evidence

ORD record
ord-823f3e8b3e614743a2287565f4ae6021
Source dataset
uspto-grants-2015_06
Patent number
US09051290B2

Reaction notes

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