HCID 12649190, compound → HCID 117647035, compound

HRID 2171215Notes

Reaction equation

HRID 2171215 reaction equation
[CH3:1][N:2]([CH3:16])[C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N+:12]([O-])=O)[CH:10]=2)[N:5]([CH3:15])[N:4]=1>[Pd].CO>[CH3:1][N:2]([CH3:16])[C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([NH2:12])[CH:10]=2)[N:5]([CH3:15])[N:4]=1

Participants

4

Reactant 1

HCID 12649190HCID 12649190, compound

Product 1

HCID 117647035HCID 117647035, compoundYield 87.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

An MeOH (10 ml) solution containing N,N,1-trimethyl-5-nitro-1H-indazol-3-amine (132 mg) obtained in the 2nd step was prepared and subjected to a hydrogenation reaction (70° C.; 50 bar; flow rate: 2 ml/min; 10% Pd/C) using H-Cube™. The solvent was distilled away under, reduced pressure. A red solid of N3,N3,1-trimethyl-1H-indazol-3,5-diamine (100 mg) was thus obtained.

Workup

  1. customobtained in the 2nd step
  2. customwas prepared
  3. distillationThe solvent was distilled away under, reduced pressure

Sources & evidence

ORD record
ord-2b6fa177ebe34a36ac9e89d93240da9e
Source dataset
uspto-grants-2015_06
Patent number
US09051310B2

Reaction notes

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