Stannous Chloride → HCID 89666797, compound

HRID 2171222Notes

Reaction equation

HRID 2171222 reaction equation
[Sn](Cl)Cl.[Cl:4][C:5]1[CH:6]=[C:7]([N+:15]([O-])=O)[CH:8]=[C:9]2[C:13]=1[N:12]([CH3:14])[N:11]=[CH:10]2>C(O)C>[Cl:4][C:5]1[CH:6]=[C:7]([NH2:15])[CH:8]=[C:9]2[C:13]=1[N:12]([CH3:14])[N:11]=[CH:10]2

Participants

4

Reactant 2

HCID 24479Stannous ChlorideHCID 12558563HCID 12558563, compound

Product 1

HCID 89666797HCID 89666797, compoundYield 38.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

Tin (II) chloride (50 mg) was added to a ethanol (2 ml) solution containing 7-chloro-1-methyl-5-nitro-1H-indazole (30 mg), followed by stirring at 100° C. for 0.5 hours. The solvent was distilled away under reduced pressure and the obtained residue was purified by silica gel chromatography (n-hexane:ethyl acetate=1:0 to 0:1). 7-Chloro-1-methyl-1H-indazol-5-amine (10 mg) was thus obtained.

Workup

  1. distillationThe solvent was distilled away under reduced pressure
  2. customthe obtained residue was purified by silica gel chromatography (n-hexane:ethyl acetate=1:0 to 0:1)

Sources & evidence

ORD record
ord-969c6318353e4f679f37d5e92160dccb
Source dataset
uspto-grants-2015_06
Patent number
US09051310B2

Reaction notes

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