tert-Butanol → HCID 89666804, compound

Participants

Reaction Conditions

Reaction Steps

Triethylamine (158 μl), tert-butanol, and DPPA (246 μl) were added to a toluene (5 ml) solution containing 5-fluoro-6-(2H-1,2,3-triazol-2-yl)nicotinic acid (198 mg) obtained in the 1st step, followed by stirring at 100° C. for 1 hour. The reaction solution was adjusted to room temperature and the solvent was distilled away under reduced pressure. The obtained residue was purified by silica gel chromatography (n-hexane:ethyl acetate=4:1 to 1:1) and a white solid of tert-butyl (5-fluoro-6-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)carbamate (94 mg) was thus obtained.

Provenance & Evidence