反应详情

Morpholine (3 ml) was added to 2-chloro-3-fluoropyridin-4-amine (133 mg) obtained in the 2nd step, followed by microwave irradiation (Initiator™, 180° C., 20 minutes, 2.45 GHz, 0-240 W). A saturated ammonium chloride aqueous solution was added to the reaction solution, followed by extraction with ethyl acetate. The organic layers were washed with a saturated ammonium chloride aqueous solution and saturated saline and dried over anhydrous sodium sulfate. The solvent was distilled away under reduced pressure. A light brown solid of 3-fluoro-2-morpholinopyridin-4-amine (153 mg) was thus obtained.

1. customobtained in the 2nd step
2. customfollowed by microwave irradiation (Initiator™, 180° C., 20 minutes, 2.45 GHz, 0-240 W)
3. extractionfollowed by extraction with ethyl acetate
4. washThe organic layers were washed with a saturated ammonium chloride aqueous solution and saturated saline
5. dry with materialdried over anhydrous sodium sulfate
6. distillationThe solvent was distilled away under reduced pressure