Morpholine → HCID 68027921, 화합물

HRID 2171253노트

반응식

HRID 2171253 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[C:8]1[C:13]([F:14])=[C:12]([NH2:15])[CH:11]=[CH:10][N:9]=1.[Cl-].[NH4+]>>[F:14][C:13]1[C:8]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[N:9][CH:10]=[CH:11][C:12]=1[NH2:15]

참가 물질

4

반응물 3

HCID 8083MorpholineHCID 25517Ammonium ChlorideHCID 601502892-Chloro-3-fluoropyridin-4-amine

생성물 1

HCID 68027921HCID 68027921, 화합물

실험 절차

Morpholine (3 ml) was added to 2-chloro-3-fluoropyridin-4-amine (133 mg) obtained in the 2nd step, followed by microwave irradiation (Initiator™, 180° C., 20 minutes, 2.45 GHz, 0-240 W). A saturated ammonium chloride aqueous solution was added to the reaction solution, followed by extraction with ethyl acetate. The organic layers were washed with a saturated ammonium chloride aqueous solution and saturated saline and dried over anhydrous sodium sulfate. The solvent was distilled away under reduced pressure. A light brown solid of 3-fluoro-2-morpholinopyridin-4-amine (153 mg) was thus obtained.

후처리

  1. customobtained in the 2nd step
  2. customfollowed by microwave irradiation (Initiator™, 180° C., 20 minutes, 2.45 GHz, 0-240 W)
  3. extractionfollowed by extraction with ethyl acetate
  4. washThe organic layers were washed with a saturated ammonium chloride aqueous solution and saturated saline
  5. dry with materialdried over anhydrous sodium sulfate
  6. distillationThe solvent was distilled away under reduced pressure

출처 및 근거

ORD 기록
ord-30822e98d6eb4114b5efe4ec82207cf6
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09051310B2

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